About Contact Events News. Search Search. You and Your Hormones. Students Teachers Patients Browse. Human body. Home Hormones Follicle stimulating hormone. Follicle stimulating hormone Follicle stimulating hormone is produced by the pituitary gland. It regulates the functions of both the ovaries and testes. Lack or insufficiency of it can cause infertility or subfertility both in men and women. Alternative names for follicle stimulating hormone FSH; follitropin pharmaceutical preparations What is follicle stimulating hormone?
How is follicle stimulating hormone controlled? What happens if I have too much follicle stimulating hormone? What happens if I have too little follicle stimulating hormone? Last reviewed: Feb Prev. Related Glands. Related Endocrine Conditions.
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Home About us News Contact. Paswoord Paswoord vergeten? Inloggen Annuleren. The name luteinizing hormone derives from this effect of inducing luteinization of ovarian follicles.
As its name implies, FSH stimulates the maturation of ovarian follicles. Administration of FSH to humans and animals induces "superovulation", or development of more than the usual number of mature follicles and hence, an increased number of mature gametes.
FSH is also critical for sperm production. It supports the function of Sertoli cells, which in turn support many aspects of sperm cell maturation. GnRH is a ten amino acid peptide that is synthesized and secreted from hypothalamic neurons and binds to receptors on gonadotrophs. As depicted in the figure to the right, GnRH stimultes secretion of LH, which in turn stimulates gonadal secretion of the sex steroids testosterone, estrogen and progesterone.
In a classical negative feedback loop , sex steroids inhibit secretion of GnRH and also appear to have direct negative effects on gonadotrophs. In females, pulse frequency is clearly related to stage of the cycle.
Numerous hormones influence GnRH secretion, and positive and negative control over GnRH and gonadotropin secretion is actually considerably more complex than depicted in the figure. For example, the gonads secrete at least two additional hormones - inhibin and activin - which selectively inhibit and activate FSH secretion from the pituitary. This condition is typically manifest in males as failure in production of normal numbers of sperm.
In females, cessation of reproductive cycles is commonly observed.
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